Table 2.
The interaction SNP pairs identified for type 2 diabetes mellitus
| SNP pair | Chr | Positiona | Geneb | Allelec | GENEVA |
IPM |
Combined P valued | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | CR | OR (95% CI) | P value | MAF | CR | OR (95% CI) | P value | ||||||
| rs4947941 | 7 | 54871175 | RP11-745C15.2 | T/C | 0.443 | 1 | 1.00 (0.98–1.02) | 0.824 | 0.424 | 1 | 0.97 (0.92–1.02) | 0.831 | 0.911 |
| rs7785013 | 7 | 55152667 | EGFR | A/G | 0.158 | 0.999 | 1.00 (0.98–1.03) | 0.830 | 0.137 | 0.999 | 0.98 (0.91–1.05) | 0.977 | 0.998 |
| rs494794×rs7785013 | - | - | - | - | - | - | 0.91 (0.88–0.95) | 9.41×10−7 | - | - | 0.78 (0.70–0.86) | 1.73×10−6 | 4.84×10−10 |
SNP, single nucleotide polymorphism; Chr, chromosome; GENEVA, Gene Environment Association Studies initiative in Type 2 Diabetes; IPM, Biobank Program of the Institute of Personalized Medicine; MAF, minor allele frequency; CR, call rate; OR, odds ratio; CI, confidence interval; EGFR, epidermal growth factor receptor.
a
Position was relative to the hg19 version of the human genome,
b
The physical location of identified SNP,
c
The former allele represents the minor allele,
d
Meta-analyses results by using two genome-wide association study samples.