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. 2021 Mar 8;35(4):968–981. doi: 10.1038/s41375-021-01204-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Shown are main cellular interactions in the cHL microenvironment that promote the survival and/or proliferation of HRS cells. The HRS cell-supporting immune cells and fibroblasts are actively recruited into the microenvironment by a multitude of cytokines and chemokines secreted by the HRS cells. HRS cells in many cHL cases still express MHC class II, so that in addition to the interactions between HRS cells and CD4⁺ Th cells shown also a binding of MHC class II to the TCR is possible (not depicted).