. 2020 Aug 21;35(4):1001–1011. doi: 10.1038/s41375-020-01024-0

Table 1.

Patient characteristics of patients aged < 18 years with acute lymphoblastic leukaemia in the Netherlands between 1990 and 2015.

	Total		Average per year	Period of diagnosis										p-Chi2
	Total		Average per year	1990–94		1995–99		2000–04		2005–09		2010–2015^c		p-Chi2
	N	%	N	N	%	N	%	N	%	N	%	N	%
	2997		115	481	16%	589	20%	640	21%	585	20%	702	23%
Age groups (years)														0.04
0	90	3%	3	10	2%	16	3%	24	4%	22	4%	18	3%
1–4	1385	46%	53	237	49%	292	50%	295	46%	244	42%	317	45%
5–9	796	27%	31	129	27%	149	25%	166	26%	180	31%	172	25%
10–14	479	16%	18	65	14%	89	15%	114	18%	84	14%	127	18%
15–17	247	8%	10	40	8%	43	7%	41	6%	55	9%	68	10%
Sex														0.02
Male	1744	58%	67	266	55%	373	63%	383	60%	325	56%	397	57%
Female	1253	42%	48	215	45%	216	37%	257	40%	260	44%	305	43%
Site of treatment														<0.01
Paediatric oncology centre	2882	96%	111	452	94%	558	95%	619	97%	567	97%	686	98%
Outside paediatric oncology centre	115	4%	4	29	6%	31	5%	21	3%	18	3%	16	2%
Immunophenotype^a														0.16
BCP-ALL	2562	86%	99	412	87%	502	86%	556	87%	489	84%	603	86%
T-cell ALL	424	14%	16	64	13%	84	14%	83	13%	95	16%	98	14%
Unknown (<1% of total)^b	11		0	5		3		1		1		1
Down syndrome (only for pts in DCOG registry)														0.31
Yes	77	3%	3	9	2%	16	3%	14	2%	22	4%	16	2%
No	2805	97%	108	443	98%	542	97%	605	98%	545	96%	670	98%
Unknown	115			29		31		21		18		16

BCP-ALL B-cell precursor acute lymphoblastic leukaemia.

^aAs confirmed by the DCOG laboratory, if not known in the DCOG registry, the NCR morphology code was taken.

^bUnknown if not known in the DCOG registry.

^c6 years period.