Table 2.
Multivariable analysis for the risk of dying from acute lymphoblastic leukaemia for patients aged < 18 years in the Netherlands between 1990 and 2015.
| N | HRa | 95% CI | P value | |
|---|---|---|---|---|
| Period | ||||
| 1990–94 | 481 | Ref. | ||
| 1995–99 | 589 | 0.9 | 0.7–1.2 | 0.56 |
| 2000–04 | 640 | 0.7 | 0.5–0.9 | 0.01 |
| 2005–09 | 585 | 0.5 | 0.1–0.3 | <0.01 |
| 2010–15 | 702 | 0.4 | 0.1–0.3 | <0.01 |
| Sex | ||||
| Male | 1744 | Ref. | ||
| Female | 1253 | 0.9 | 0.7–1.1 | 0.19 |
| Age groups (years) | ||||
| 0 | 90 | 8.2 | 5.8–12 | <0.01 |
| 1–4 | 1385 | Ref. | ||
| 5–9 | 796 | 1 | 0.8–1.4 | 0.79 |
| 10–14 | 479 | 2.1 | 1.6–2.8 | <0.01 |
| 15–17 | 247 | 3.5 | 2.6–4.7 | <0.01 |
| Immunophenotype | ||||
| BCP-ALL | 2562 | Ref. | ||
| T-cell ALL | 424 | 1.9 | 1.5–2.4 | <0.01 |
| Unknown | 11 | ND | ||
BCP-ALL B-cell precursor acute lymphoblastic leukaemia, HR hazard ratio, CI confidence interval, ND not done.
aIn this multivariable analysis, each covariate is simultaneously adjusted for all other covariates and follow-up time. Hazard ratios represent risk of death within 5 years from diagnosis compared to the reference category.