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. 2021 Jan 27;35(4):1037–1052. doi: 10.1038/s41375-020-01115-y

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

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Fig. 3 — A Representative flow cytometry histogram of MSI2 expression in MEC1, CRL-2261 (non-Hodgkin’s lymphoma), and Ramos (Burkitt’s lymphoma) untreated (black) or treated with siCTR (blue) or with siMSI2 (red). Dotted line is the isotype control for each condition. B MSI2 protein levels (siMSI2:siCTR) in each cell line in triplicate (upper panel). Number of viable cells in each cell line treated with siCTR (blue) or with siMSI2 (red) (lower panel). C Representative histogram of MSI2 expression in CD19⁺CD5⁺ cells treated with siCTR (blue) or siMSI2 (red). The isotype control for each condition is shown as dashed lines. D MSI2 expression in CLL cells treated with siCTR and siMSI2 in co-culture with HS5; stimulated with CpG-ODN + IL15; and stimulated with CpG-ODN + IL15 in co-culture with HS5. E Percentage of live cells after siRNA treatment. Paired t-test analysis was performed for each CLL patient. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.