Fig. 3.

TPATEM/TPA-test findings in COVID-19 patients. Representative TPATEM curves from a healthy donor (green curve), a COVID-19 patient without thrombosis (black curve), and a COVID-19 patient with thrombosis (red curve). In COVID-19 patients, LOT and LT are prolonged, and MCF and LI30 are increased compared with those in healthy controls after r-tPA challenge (TPATEM = EXTEM + 0.625 µg/ml r-tPA). CF: clot firmness in mm, CT: coagulation time in seconds, EXTEM: ROTEM^® test assessing the extrinsic coagulation pathway, LI30: lysis index 30 min after CT in % of MCF, LOT: lysis onset time in seconds, MCF: maximum clot firmness in mm, ML: maximum lysis in % of MCF, and r-tPA: recombinant tissue plasminogen activator. Courtesy of Klaus Görlinger, Munich, Germany.