Table 2.
Baseline clinical and laboratory parameters for critically-ill COVID-19 patients
| Parameter | Total patients (n = 87) | Control group (n = 44) | Intervention (TPE) group (n = 43) |
|---|---|---|---|
| Systolic blood pressure (mmHg) | 94 (83–105) | 98.5 (85–113.5) | 92 (80–104) |
| Diastolic blood pressure (mmHg) | 50 (39–69) | 49 (39–69) | 52 (40–64) |
| Noradrenaline infusion (μg/kg/h) | 1 (0.8–1.2) | 1 (0.7–1.2) | 1.0 (0.8–1.2) |
| White blood cell count (cells/mm3) (normal range, 4000–10 000) | 12 000 (6000–18 000) | 12 000 (6200–17 800) | 12 000 (6000–18 000) |
| Lymphocytes (109/L) (normal range, 1.1–3.2) | 0.5 (0.2–0.8) | 0.6 (0.2–1) | 0.5 (0.2–0.7)* |
| Platelets (cells/mm3) (normal range, 150 000–450 000) | 128 000 (109 000–185 000) | 126 000 (103 000–196 000) | 129 000 (9700–176 000) |
| Prothrombin time (s) (normal range, 9–12) | 13 (11–15) | 13 (10.8–16.1) | 12 (10–14) |
| Partial thromboplastin time (s) (normal range, 26–36) | 43 (29–52) | 43 (28–51) | 43 (33–52) |
| International normalisation ratio (normal range, 0.8–1.2) | 1.10 (0.8–1.4) | 1.10 (0.8–1.4) | 1.10 (0.8–1.4) |
| ADAMTS-13 activity (%) (normal range, 53–205) | 19 (6–34) | 21 (7.7–35.3) | 17 (6–38)* |
| Creatinine (mg/dL) (normal range, 0.6–1.2) | 1.0 (0.8–1.3) | 1.0 (0.8–1.2) | 1.1 (0.9–1.3) |
| Total bilirubin (μmol/L) (normal range, 0–26) | 33 (23–39) | 33.5 (20.2–38.8) | 33 (23–39) |
| Serum lactate (mmol/L) (normal range, 1.0–2.5) | 4 (1–7) | 4 (1–7) | 5 (2–8) |
| Alanine aminotransferase (U/L) (normal range, 9–50) | 56 (37–76) | 55.5 (40.2–68.8) | 56 (31–78) |
| Aspartate aminotransferase (U/L) (normal range, 15–40) | 45 (27–65) | 46.5 (20.2–66.8) | 43.0 (22.8–63.8) |
| C-reactive protein (mg/L) (normal range, 0–5) | 234 (112–355) | 234 (109–359) | 246 (157–356) |
| Lactate dehydrogenase (U/L) (normal range, 100–190) | 589 (109–1099) | 378 (100–656) | 876 (546–1206)* |
| Ferritin (ng/mL) (normal range, 23–336) | 569 (129–1161) | 320 (75–675) | 987 (319–1655)* |
| d-dimers (μg/mL) (normal values, <1) | 4 (1.4–7.6) | 2.5 (1.4–4.6) | 4.9 (2.9–7.9)* |
| Interleukin-6 (pg/mL) (normal range, 1–7) | 232 (55–809) | 122.5 (48.7–262.8) | 458 (225–1091)* |
NOTE: Values are the median and interquartile range.
TPE, therapeutic plasma exchange.
⁎
P ≤ 0.05 was considered statistically significant by Wilcoxon signed-rank test for non-parametric data between controls and patients who underwent TPE.