Table 4.
Cox proportional hazards model for 35-day mortality in the total COVID-19 patients (n = 87)
| Univariate model | Multivariable model | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |||
| Effect of TPE on mortality | 0.81 | 0.35 | 1.87 | 0.62 | – | – | – | – |
| Age (years) | 1.04 | 0.99 | 1.09 | 0.07 | – | – | – | – |
| PaO2/FiO2 ratio | 0.97 | 0.95 | 0.99 | 0.001 | 0.98 | 0.96 | 1.00 | 0.02 |
| APACHE II score | 1.23 | 0.93 | 1.63 | 0.16 | – | – | – | – |
| SOFA score | 1.33 | 1.04 | 1.69 | 0.02 | – | – | – | – |
| ADAMTS-13 activity (%) | 0.88 | 0.82 | 0.94 | 0.0001 | 0.89 | 0.82 | 0.98 | 0.01 |
| Interleukin-6 (pg/mL) | 1.1 | 1.00 | 1.2 | 0.08 | – | – | – | – |
| d-dimers (μg/mL) | 1.29 | 1.12 | 1.48 | 0.01 | – | – | – | – |
| Pulmonary embolism | 5.50 | 2.40 | 12.61 | 0.0001 | 3.57 | 1.43 | 8.92 | 0.007 |
| High risk (>3 criteria) for CRS | 6.07 | 0.82 | 45.19 | 0.08 | – | – | – | – |
HR, hazard ratio; CI, confidence interval; TPE, therapeutic plasma exchange; PaO2/FiO2, partial arterial pressure of oxygen/fractional inspired concentration of oxygen; APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Function Assessment; CRS, cytokine release syndrome.