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. 2021 Apr 6;12(4):357. doi: 10.1038/s41419-021-03644-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Schematic diagram shows in vivo assessment MSC-CM treatment efficacies in LPS-induced neuroinflammation animal model. Open-field-test was used as the main behavioral readout. Boxplots show ambulatory distance (B) and episodes (C) of the open-field-test of each treatment groups. All data were normalized to the average value of the LPS group. D Boxplot shows inflammatory factors TNF-α mRNA levels in hippocampus of each group. Data were also normalized to the average value of the LPS group, and presented as mean ± SEM, *P < 0.05, **P < 0.01, ****P < 0.0001.