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. 2021 Apr 6;12(4):357. doi: 10.1038/s41419-021-03644-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Anti-inflammation genes IDO1, CXCL9 and IL6 were extensively up-regulated in huMSCs by stimulation of TNF-α and IFN-γ (2-factors). B In vitro analysis on BV2 inhibition showed elimination of donor-dependent variations in immune-modulations by two factors. C–E eradication of specific donor-dependent variations of huMSCs regarding treatment efficacies in LPS-induced neuroinflammation model, by open-field-motor scoring and hippocampal TNF-α expression. All data were normalized to LPS group, and were presented as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.