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. 2021 Apr 6;6:48. doi: 10.1038/s41541-021-00310-x

Fig. 8. NAV PBS and NAV DPBS vaccination reduced antiviral and inflammatory response gene expression following viral challenge.

Fig. 8

Expression microarray analysis was performed on total RNA isolated from lungs on days 3 and 6 post-challenge (n = 5 mice per condition per time point). a Heatmaps showing expression of antiviral and inflammatory response genes identified by ANOVA (p < 0.001) that showed >2-fold change in expression between PBS, NAV PBS, and NAV DPBS vaccinated groups on day 3 post-viral challenge. Due to the small number of sequences (n = 69) identified at this timepoint, pathway classification analysis was not performed (gene IDs are shown in Supplemental Figs. 1 and 2). b Heatmap showing expression of antiviral/immune response genes identified by ANOVA (p < 0.001 with >2-fold change in expression) on day 6 post-viral challenge. Red indicates higher expression of sequences in infected mouse lung compared to normal unvaccinated, uninfected, age-matched mouse lung, while green indicates lower expression, and black indicates no change. c Pathway classification of genes identified by ANOVA on day 6 post-viral challenge.