Table 2.

Relative mRNA quantification for selected genes in liver of WT and Pah-R261Q mice.

Gene (name)	Pah genotype	Expression level (relative to WT mice, defined as 1)	Fold changea	p Valueb
Pah	WT	1.0000 (0.7878 ± 1.2693)	1.15	0.2273
	R261Q	1.1524 (1.0967 ± 1.2110)
Gch1	WT	0.2512 (0.2146 ± 0.2939)	1.08	0.5440
	R261Q	0.2714 (0.2115 ± 0.3483)
Gchfr	WT	0.0163 (0.0131 ± 0.0203)	1.70	0.0024
	R261Q	0.0277 (0.0228 ± 0.0336)
Dnajc12	WT	0.0040 (0.0030 ± 0.0053)	1.78	0.0048
	R261Q	0.0071 (0.0057 ± 0.0088)
Hsp70	WT	0.0010 (0.0007 ± 0.0015)	0.31	0.0012
	R261Q	0.0003 (0.0002 ± 0.0005)
Hsc70	WT	0.9704 (0.7478 ± 1.2592)	1.34	0.0855
	R261Q	1.2983 (1.0279 ± 1.6399)
Hsf1	WT	0.0280 (0.0251 ± 0.0313)	0.65	0.0054
	R261Q	0.0183 (0.0140 ± 0.0238)
Stub1	WT	0.0156 (0.0126 ± 0.0193)	1.22	0.0808
	R261Q	0.0191 (0.0175 ± 0.0208)
Sqstm1	WT	0.2483 (0.2203 ± 0.2799)	1.04	0.6389
	R261Q	0.2571 (0.2287 ± 0.2892)
Ap-1	WT	0.0163 (0.0140 ± 0.0189)	1.0	0.9815
	R261Q	0.0163 (0.0149 ± 0.0179)

^aFold change in Pah-R261Q mice relative to WT mice.

^bTwo-tailed p values for differences between both mice groups, obtained from the Mann Whitney U test.

Genes upregulated or downregulated in Pah-R261Q (n = 5 mice) compared to WT (n = 6 mice) (p < 0.05) are highlighted in bold text.