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. 2021 Apr 6;12:2074. doi: 10.1038/s41467-021-22205-0

Fig. 3. Multiple sensory pathways are involved in tFO-induced hypothermia.

Fig. 3

a Temporal and mean cutaneous temperature of olfactory bulbectomized (OBx; n = 12) and sham-operated (n = 8) animals in response to eugenol (EG) and 2MT presentation are shown; p = 0.6302 for eugenol presentation (1–10 min) and p < 0.0001 for 2MT presentation (11–20 min). b Temporal and mean cutaneous temperature of ΔD (Omacs-Cre; NSE-DTAflox) and control mice (n = 8 each) in response to EG and 2MT presentation are shown; p = 0.722 for EG presentation (1–10 min) and p = 0.0052 for 2MT presentation (21–30 min). c Temporal and mean cutaneous temperature of unilateral trigeminal ganglion (TG)-lesioned and sham-operated animals (n = 8 each) in response to EG and 2MT presentation are shown; p = 0.8921 for EG presentation (1–10 min) and p < 0.0001 for 2MT presentation (11–20 min). d Temporal and mean cutaneous temperature of olfactory neuron (ON)-specific Trpa1 knockout (Omp-Cre; Trpa1flox/flox) and control mice (n = 5 for control and n = 8 for knockout) in response to 2MT presentation are shown; p = 0.9757 for baseline condition (1–10 min) and p = 0.9943 for 2MT presentation (21–30 min). e Temporal and mean cutaneous temperature of sensory neuron (SN)-specific Trpa1 knockout (Adv-Cre; Trpa1flox/flox) and control mice (n = 10 each) are shown; p = 0.9775 for baseline condition (1–10 min) and p = 0.0249 for 2MT presentation (21–30 min). f Temporal and mean cutaneous temperature of intra-trigeminal ganglion injection of saline and RTX (n = 8 for saline and n = 11 for RTX) in response to 2MT presentation are shown; p = 0.5719 for baseline condition (1–10 min) and p = 0.0034 for 2MT presentation (11–20 min). Data are shown as mean ± SEM. Two-way ANOVA followed by Sidak’s multiple comparison test; **p < 0.01; ***p < 0.001. Scale bars, 100 µm.