Table 1.

Univariate and multivariate cox regression of prognostic factors for survival of patients with CRC.

Characteristic	Univariate analysis		Multivariate analysis
	HR value	P value	HR value	P value
Age
≤60	Reference	–
>60	0.988(0.69–1.416)	0.949
Gender
Male	Reference	–
Female	0.779(0.393–1.545)	0.475
TNM staging
I/II	Reference	–	Reference	–
III/IV	4.669(2.297–9.947)	0.000	3.547(2.077–8.765)	0.000
Tumor type
Protuberant	Reference	–
Infiltrative	3.505(1.077–11.41)	0.037
Ulcerative	1.905(0.653–5.554)	0.238
Adenocarcinoma Pathological grade
I	Reference	–
II	1.531(0.577–4.061)	0.392
III	3.095(1.01–9.484)	0.048
Lymph node metastasis
No	Reference	–	Reference	0.000
Yes	4.237(2.111–8.507)	0.000	4.017(2.324–8.417)
Tumor size
≥5 cm	Reference	–	Reference
<5 cm	1.823(0.902–3.685)	0.045	1.769(0.806–3.575)	0.078
T stage
T1/T2	Reference	–
T3/T4	2.357(0.568–9.095	0.236
Distant metastasis
No	Reference	–	Reference
Yes	4.757(1.604–14.12)	0.005	4.307(1.459–13.075)	0.008
RNF31 expression
Low	Reference	–	Reference
High	2.458(1.112–5.443)	0.026	2.014(1.104–5.923)	0.037
P53 expression
Low	Reference	–	Reference
High	0.287(0.125–0.66)	0.003	0.351(0.145–0.776)	0.005

Italic values indicate statistical significance when P < 0.05.