Table 2.
Multivariate Cox analysis showed that high expression of ADCK1 had significant prognostic value.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| ADCK1 | 0.007* | 0.014* | ||||
| High | 2.882 | 1.33–6.241 | 2.679 | 1.226–5.855 | ||
| Low | Ref | Ref | Ref | Ref | ||
| Distant metastasis | 0.008* | 0.016* | ||||
| Yes | 2.612 | 1.291–5.282 | 2.373 | 1.175–4.796 | ||
| No | Ref | Ref | Ref | Ref | ||
| Clinical stages | 0.031* | |||||
| III–IV | 2.570 | 1.092–6.049 | ||||
| I–II | Ref | Ref | ||||
| Lymph node metastasis | 0.658 | |||||
| Yes | 1.173 | 0.578–2.381 | ||||
| No | Ref | Ref | ||||
| Chemotherapy regimen | ||||||
| XELOX, XELOX + radiation therapy | 5740.710 | 0–7.914E+84 | 0.928 | |||
| FOLFOX, FOLFOX + radiation therapy | 14,253.195 | 0–1.964E+85 | 0.920 | |||
| Others | Ref | Ref | ||||
| Variables in equations | ||||||||
|---|---|---|---|---|---|---|---|---|
| B | Standard error of | Wald | Degrees of freedom | Significant | Exp (B) | 95% Confidence interval for exp (B) | ||
| The lower limit | Ceiling | |||||||
| Step 1 | ||||||||
| ADCK1 | 0.847 | 0.412 | 4.228 | 1 | 0.040 | 2.332 | 1.040 | 5.226 |
| Metastasis | 0.725 | 0.541 | 1.792 | 1 | 0.046 | 2.074 | 1.012 | 4.252 |
| Clinical stages | 0.009 | 0.749 | 0.000 | 1 | 0.991 | 1.009 | 0.233 | 4.377 |
| Lymph node metastasis | −0.397 | 0.506 | 0.614 | 1 | 0.433 | 0.673 | 0.249 | 1.814 |
| Chemoradiotherapy regimen | 4.384 | 2 | 0.112 | 2.528 | 1.061 | 6.024 | ||
| Chemoradiotherapy regimen (1) | 0.928 | 0.443 | 4.384 | 1 | 0.036 | 0.000 | 0.000 | |
| Chemoradiotherapy regimen (2) | −11.189 | 479.777 | 0.001 | 1 | 0.981 | 0.000 | 0.000 | – |
| Step 2 | ||||||||
| ADCK1 | 0.848 | 0.399 | 4.511 | 1 | 0.034 | 2.335 | 1.068 | 5.105 |
| Metastasis | 0.730 | 0.366 | 3.968 | 1 | 0.181 | 2.064 | 0.714 | 5.966 |
| Lymph node metastasis | −0.393 | 0.412 | 0.913 | 1 | 0.339 | 0.675 | 0.301 | 1.512 |
| Chemoradiotherapy regimen | 4.403 | 2 | 0.111 | |||||
| Chemoradiotherapy regimen (1) | 0.928 | 0.442 | 4.402 | 1 | 0.036 | 2.529 | 1.063 | 6.017 |
| Chemoradiotherapy regimen (2) | −11.190 | 479.754 | 0.001 | 1 | 0.981 | 0.000 | 0.000 | – |
| Step 3 | ||||||||
| ADCK1 | 0.870 | 0.397 | 4.798 | 1 | 0.028 | 2.386 | 1.096 | 5.197 |
| Metastasis | 0.772 | 0.363 | 4.510 | 1 | 0.034 | 2.163 | 1.061 | 4.409 |
| Chemoradiotherapy regimen | 3.418 | 2 | 0.181 | |||||
| Chemoradiotherapy regimen (1) | 0.718 | 0.389 | 3.417 | 1 | 0.065 | 2.051 | 0.958 | 4.392 |
| Chemoradiotherapy regimen (2) | −11.077 | 472.043 | 0.001 | 1 | 0.981 | 0.000 | 0.000 | – |
| Step 4 | ||||||||
| ADCK1 | 0.985 | 0.399 | 6.102 | 1 | 0.014 | 2.679 | 1.226 | 5.855 |
| Metastasis | 0.864 | 0.359 | 5.799 | 1 | 0.016 | 2.373 | 1.175 | 4.796 |
HR hazard odds, CI confidence interval.
*P < 0.05.