Table 2.
Associations of B7-H6 and PD-L1 expression with clinical parameters in Her2 positive primary breast cancer patients.
| Clinical pathological parameter | All patients n = 50 | B7-H6 BCC | p value | TILs-B7-H6 | p value | PD-L1 BCC | p value | TILs-PD-L1 | p value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < median n = 22 | ≥ median n = 28 | Low n = 39 | High n = 8 | UnK n = 3 | < median n = 41 | ≥ median n = 9 | Low n = 15 | High n = 32 | Unk n = 3 | ||||||
| Age in years | 0.77 | 0.75 | 0.11 | 0.38 | |||||||||||
| < median = 48 | 27 | 11 | 16 | 22 | 5 | 0 | 20 | 7 | 10 | 17 | 0 | ||||
| ≥ median = 48 | 23 | 11 | 12 | 17 | 3 | 3 | 21 | 2 | 5 | 15 | 3 | ||||
| Histological type | 1 | 0.34 | 0.26 | 0.75 | |||||||||||
| IDC | 45 | 20 | 25 | 35 | 8 | 2 | 36 | 9 | 14 | 29 | 2 | ||||
| Others | 5 | 2 | 3 | 4 | 0 | 1 | 5 | 0 | 1 | 3 | 1 | ||||
| ER | 0.61 | 0.11 | 0.26 | 0.68 | |||||||||||
| Negative | 25 | 11 | 14 | 18 | 6 | 1 | 19 | 6 | 7 | 17 | 1 | ||||
| Positive | 25 | 11 | 14 | 21 | 2 | 2 | 22 | 3 | 8 | 15 | 2 | ||||
| PR | 0.77 | 0.85 | 0.76 | 0.96 | |||||||||||
| Negative | 30 | 14 | 16 | 23 | 5 | 2 | 25 | 5 | 9 | 19 | 2 | ||||
| Positive | 20 | 8 | 12 | 16 | 3 | 1 | 16 | 4 | 6 | 13 | 1 | ||||
| Molecular Subtypes | 0.94 | 0.32 | 0.91 | 0.52 | |||||||||||
| H | 22 | 10 | 12 | 17 | 5 | 0 | 18 | 4 | 6 | 16 | 0 | ||||
| LB | 28 | 12 | 16 | 22 | 3 | 3 | 23 | 5 | 9 | 16 | 3 | ||||
| SBR grading | 0.025* | 0.10 | 0.035* | 0.75 | |||||||||||
| I | 3 | 3 | 0 | 2 | 0 | 1 | 3 | 0 | 1 | 1 | 1 | ||||
| II | 22 | 12 | 10 | 19 | 1 | 2 | 21 | 1 | 7 | 13 | 2 | ||||
| III | 25 | 7 | 18 | 18 | 7 | 0 | 17 | 8 | 7 | 18 | 0 | ||||
| Tumor size (cm) | 0.92 | 0.80 | 0.43 | 0.13 | |||||||||||
| T1 ≤ 2 | 8 | 3 | 5 | 5 | 2 | 1 | 7 | 1 | 0 | 7 | 1 | ||||
| 2 < T2 ≤ 5 | 24 | 11 | 13 | 19 | 4 | 1 | 18 | 6 | 9 | 14 | 1 | ||||
| T3 > 5 | 8 | 3 | 5 | 7 | 1 | 0 | 8 | 0 | 2 | 6 | 0 | ||||
| T4 | 10 | 5 | 5 | 8 | 1 | 1 | 8 | 2 | 4 | 5 | 1 | ||||
| Lymphe Node status | 0.89 | 0.055 | 0.53 | 0.21 | |||||||||||
| N0 | 9 | 5 | 4 | 6 | 3 | 0 | 6 | 3 | 1 | 8 | 0 | ||||
| N1 | 19 | 8 | 11 | 16 | 0 | 3 | 17 | 2 | 8 | 8 | 3 | ||||
| N2 | 12 | 5 | 7 | 8 | 4 | 0 | 10 | 2 | 3 | 9 | 0 | ||||
| N3 | 10 | 4 | 6 | 9 | 1 | 0 | 8 | 2 | 3 | 7 | 0 | ||||
| Metastasis | 0.84 | 0.11 | 0.51 | 0.35 | |||||||||||
| M0 | 29 | 14 | 15 | 21 | 7 | 1 | 23 | 6 | 9 | 19 | 1 | ||||
| M + | 9 | 4 | 5 | 8 | 0 | 1 | 8 | 1 | 4 | 4 | 1 | ||||
| Unknown | 12 | 4 | 8 | 10 | 1 | 1 | 10 | 2 | 2 | 9 | 1 | ||||
Variable between groups presented in frequency tables evaluated by Chi-Square test. Two sided p values are considered statistically significant if < 0.05 and are indicated in bold.