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. 2021 Apr 6;12:2075. doi: 10.1038/s41467-021-22206-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Location of target VNTRs and eVNTRs relative to the proximal genes. b Pipeline to identify eVNTRs and assign causality scores. Ancestry, Sex, and PEER factors are included in C as covariates. We associate VNTR genotype with expression residuals after correcting for the effect of C. c Quantile-quantile plot showing p values of association signals separated by tissue. Green line represents the p values using 100 permutations. d Number of unique and shared eVNTRs in each tissue. e Trend of RU count correlation with gene expression level. f Spearman correlation of eVNTRs effect sizes for each pair of tissues. g Scatter plot correlating effect size versus minor allele frequency (MAF). Source data are provided as a Source Data file.