Table 3.
Joint effects for chronic fatigue syndrome between peptic ulcer disease and chronic fatigue syndrome -associated risk factors.
| Variable | N | No. of events | Rate# | Adjusted HR† | 95% CI |
|---|---|---|---|---|---|
| None | 32,540 | 152 | 0.49 | 1 | (Reference) |
| Only peptic ulcer disease | 18,917 | 196 | 1.07 | 2.22 | (1.79, 2.74)*** |
| Only diabetes | 0 | 0 | – | ||
| Only obesity | 390 | 5 | 1.27 | 2.72 | (1.11, 6.63)* |
| Only renal disease | 1310 | 15 | 1.29 | 2.27 | (1.33, 3.87)** |
| Only rheumatoid arthritis | 61 | 0 | 0 | ||
| Only HIV | 17 | 0 | 0 | ||
| Only malignancy | 1729 | 3 | 0.24 | 0.45 | (0.14, 1.43) |
| Only untreated hypothyroidism | 172 | 2 | 1.15 | 2.27 | (0.56, 9.19) |
| Only sleep apnea | 223 | 0 | 0 | ||
| Only narcolepsy | 6 | 0 | 0 | ||
| Only HBV | 840 | 8 | 0.94 | 2.05 | (1.01, 4.18)* |
| Only HCV | 251 | 1 | 0.39 | 0.73 | (0.10, 5.24) |
| Only depression | 205 | 3 | 1.48 | 2.95 | (0.94, 9.26) |
| Only anxiety | 4154 | 34 | 0.82 | 1.53 | (1.05, 2.23)* |
| Only bipolar affective disorders | 23 | 0 | 0 | ||
| Only schizophrenia | 154 | 1 | 0.71 | 1.46 | (0.21, 10.4) |
| Only delusional disorders | 26 | 0 | 0 | ||
| Only dementia | 689 | 1 | 0.2 | 0.30 | (0.04, 2.18) |
| Only anorexia or bulimia nervosa | 18 | 0 | 0 | ||
| Only alcohol or other substance abuse | 91 | 2 | 2.19 | 4.79 | (1.01, 1.02)* |
| PUD with any one comorbidity | 17,566 | 202 | 1.21 | 2.34 | (1.89, 2.89)*** |
| PUD with any two or more comorbidity | 19,011 | 247 | 1.36 | 2.52 | (2.05, 3.10)*** |
Rate# incidence rate.
No., Number; 95% CI 95%, confidence interval; HIV, human immunodeficiency virus; PUD, peptic ulcer disease.
Adjusted HR†: multivariable analysis including age, and sex.
*p < 0.05, **p < 0.01, ***p < 0.001.