Table 2.
Peripheral microRNA levels in the Idiopathic and Ischemic DCM vs. healthy control.
| microRNA | Healthy control | Idiopathic DCM | Ischemic DCM | |||||
|---|---|---|---|---|---|---|---|---|
| n | median (Q1-Q3) | n | median (Q1-Q3) | p value | n | median (Q1-Q3) | p value | |
| let-7a-5p | 44 | 6.543 (6.308–6.832) | 55 | 6.511 (6.308–7.207) | 0.6636 | 60 | 7.155 (6.507–7.626) | 0.0001 |
| let-7 g-5p | 44 | 6.268 (6.095–6.477) | 55 | 6.303 (6.095–6.939) | 0.3767 | 60 | 6.555 (6.147–7.034) | 0.0236 |
| miR-1-3p | 44 | 4.101 (3.878–4.460) | 55 | 4.238 (3.878–5.059) | 0.0611 | 60 | 4.491 (3.552–5.038) | 0.1142 |
| miR-16-5p | 44 | 7.634 (7.379–7.900) | 55 | 7.658 (7.379–8.304) | 0.0046 | 60 | 8.025 (7.714–8.300) | 0.0017 |
| miR-16–2-3p | 44 | 4.967 (4.706–5.281) | 55 | 7.035 (6.773–5.609) | 0.0043 | 60 | 5.363 (5.003–5.573) | 0.0026 |
| miR-19b-3p | 44 | 7.014 (6.773–7.230) | 55 | 6.542 (6.199–7.637) | 0.008 | 60 | 7.517 (7.103–7.751) | 0.0006 |
| miR-25-3p | 44 | 6.487 (6.199–6.751) | 55 | 6.230 (6.052–7.178) | 0.0011 | 60 | 6.917 (6.620–7.127) | 0.0017 |
| miR-29a-3p | 44 | 5.480 (5.297–5.643) | 55 | 4.951 (4.730–6.233) | 0.0001 | 60 | 5.951 (5.630–6.304) | 0.0001 |
| miR-30b-5p | 44 | 6.197 (6.052–6.431) | 55 | 4.913 (4.745–6.739) | 0.9142 | 60 | 6.525 (6.032–6.992) | 0.0229 |
| miR-30e-3p | 44 | 4.923 (4.745–5.165) | 55 | 5.072 (4.858–5.559) | 0.145 | 60 | 5.346 (4.793–5.722) | 0.0127 |
| miR-130b-3p | 44 | 5.058 (4.858–5.275) | 55 | 4.483 (4.167–5.849) | 0.0001 | 60 | 5.610 (5.056–5.904) | 0.0002 |
| miR-133a-3p | 44 | 4.451 (4.167–4.741) | 55 | 4.164 (3.843–5.412) | 0.0001 | 60 | 4.873 (4.273–5.439) | 0.0042 |
| miR-133b | 44 | 4.129 (3.843–4.437) | 55 | 6.950 (6.690–5.028) | 0.0019 | 60 | 4.491 (3.909–5.105) | 0.0026 |
| miR-142-3p | 44 | 6.932 (6.690–7.217) | 55 | 5.454 (5.279–7.588) | 0.9753 | 60 | 7.425 (7.007–8.022) | 0.0001 |
| miR-145-5p | 44 | 5.423 (5.279–5.629) | 55 | 5.504 (5.313–6.044) | 0.2254 | 60 | 5.867 (5.473–6.385) | 0.0001 |
| miR-150-5p | 44 | 5.520 (5.313–5.696) | 55 | 4.970 (4.665–6.133) | 0.1293 | 60 | 5.803 (5.377–6.053) | 0.0634 |
| miR-192-5p | 44 | 4.928 (4.665–5.152) | 55 | 6.231 (6.110–5.607) | 0.0708 | 60 | 5.293 (4.893–5.486) | 0.0075 |
| miR-199a-3p | 44 | 6.218 (6.110–6.390) | 55 | 4.512 (4.314–6.967) | 0.0007 | 60 | 6.628 (6.018–7.044) | 0.0047 |
| miR-210-3p | 44 | 4.514 (4.314–4.705) | 55 | 4.809 (4.544–5.317) | 0.0001 | 60 | 5.039 (4.683–5.478) | 0.0001 |
| miR-215-3p | 44 | 4.770 (4.544–4.997) | 55 | 5.536 (5.299–5.397) | 0.0479 | 60 | 5.101 (4.720–5.397) | 0.0098 |
| miR-324-3p | 44 | 4.892 (4.728–5.139) | 55 | 5.318 (4.969–5.554) | 0.0079 | 60 | 5.397 (4.957–5.689) | 0.0002 |
| miR-363-3p | 44 | 5.260 (4.969–5.555) | 55 | 3.845 (3.281–5.946) | 0.002 | 60 | 5.750 (5.389–5.893) | 0.0006 |
| miR-454-3p | 44 | 3.759 (3.281–4.098) | 55 | 4.704 (4.454–4.437) | 0.7829 | 60 | 4.130 (3.298–4.699) | 0.0061 |
| miR-532-5p | 44 | 4.668 (4.454–4.854) | 55 | 5.535 (5.297–5.344) | 0.083 | 60 | 5.207 (4.782–5.398) | 0.0002 |
| miR-629-5p | 44 | 4.332 (4.104–4.680) | 55 | 5.281 (4.854–5.72) | < 0.0001 | 60 | 5.182 (4.769–5.813) | < 0.0001 |
| miR-660-5p | 44 | 4.936 (4.730–5.162) | 55 | 5.436 (5.104–5.639) | 0.0001 | 60 | 5.454 (5.092–5.614) | 0.0001 |
Data presented as median (Q1-Q3). Samples size is indicated. Abbreviations: DCM. dilated cardiomyopathy.