Table 3.
Peripheral microRNA levels for LVEF categorization in idiopathic and ischemic DCM.
| microRNA | Idiopathic DCM | Ischemic DCM | ||||
|---|---|---|---|---|---|---|
| DCMSEV | DCMMOD | p value | DCMSEV | DCMMOD | p value | |
| median (Q1-Q3) | median (Q1-Q3) | median (Q1-Q3) | median (Q1-Q3) | |||
| let-7a-5p | 6.460 (5.732–7.080) | 6.909 (6.059–7.226) | 0.009 | 7.206 (6.547–7.594) | 7.125 (6.342–7.707) | 0.893 |
| let-7 g-5p | 6.272 (5.894–6.482) | 6.668 (6.000–7.010) | 0.003 | 6.712 (5.940–6.993) | 6.548 (6.138–7.054) | 0.997 |
| miR-1-3p | 4.772 (4.493–5.241) | 4.398 (2.779–4.950) | 0.003 | 4.732 (2.779–5.128) | 4.432 (3.242–4.989) | 0.995 |
| miR-16-5p | 8.127 (7.898–8.513) | 7.900 (7.619–8.221) | 0.552 | 7.930 (7.425–8.251) | 8.040 (7.681–8.301) | 0.997 |
| miR-16–2-3p | 5.386 (5.132–5.694) | 5.233 (5.016–5.559) | 0.651 | 5.338 (4.857–5.550) | 5.381 (4.994–5.588) | 0.999 |
| miR-19b-3p | 7.218 (6.949–7.581) | 7.449 (7.112–7.637) | 0.044 | 7.486 (6.814–7.671) | 7.539 (7.100–7.775) | 0.997 |
| miR-25-3p | 6.697 (6.293–7.524) | 6.938 (6.638–7.175) | 0.007 | 6.858 (6.320–7.047) | 6.919 (6.577–7.153) | 0.996 |
| miR-29a-3p | 5.746 (5.576–6.095) | 5.973 (5.718–6.258) | 0.0326 | 6.077 (5.176–6.289) | 5.949 (5.635–6.329) | 0.825 |
| miR-30b-5p | 5.880 (5.498–6.397) | 6.488 (5.634–6.862) | 0.011 | 6.684 (5.846–6.923) | 6.468 (5.982–7.027) | 0.946 |
| miR-30e-3p | 4.926 (4.563–5.320) | 5.371 (4.697–5.622) | 0.001 | 5.507 (4.551–5.699) | 5.186 (4.779–5.781) | 0.952 |
| miR-130b-3p | 5.653 (5.371–5.923) | 5.493 (5.236–5.846) | 0.956 | 5.625 (4.955–5.872) | 5.542 (5.048–5.920) | 0.834 |
| miR-133a-3p | 5.197 (4.906–5.412) | 4.895 (4.429–5.433) | 0.365 | 4.890 (3.212–5.439) | 4.851 (4.269–5.429) | 0.968 |
| miR-133b | 4.784 (4.459–5.196) | 4.434 (3.899–4.994) | 0.193 | 4.689 (3.204–5.061) | 4.485 (3.890–5.111) | 0.760 |
| miR-142-3p | 6.770 (5.961–7.348) | 7.233 (6.286–7.600) | 0.0005 | 7.749 (6.859–8.046) | 7.384 (6.741–8.023) | 0.340 |
| miR-145-5p | 5.389 (5.113–5.758) | 5.654 (5.089–6.126) | 0.005 | 6.005 (5.466–6.175) | 5.761 (5.221–6.408) | 0.998 |
| miR-150-5p | 5.539 (5.143–6.016) | 5.790 (5.418–6.156) | 0.004 | 5.446 (5.031–5.806) | 5.852 (5.451–6.066) | 0.916 |
| miR-192-5p | 5.192 (5.107–5.614) | 5.119 (4.857–5.579) | 0.438 | 5.179 (4.712–5.523) | 5.294 (4.827–5.508) | 0.757 |
| miR-199a-3p | 6.527 (6.240–6.733) | 6.715 (6.367–7.000) | 0.036 | 6.906 (5.961–7.026) | 6.544 (6.104–7.081) | 0.962 |
| miR-210-3p | 4.781 (4.340–5.179) | 5.058 (4.655–5.364) | 0.003 | 5.023 (4.382–5.479) | 5.040 (4.679–5.479) | 0.797 |
| miR-215-3p | 5.158 (4.784–5.616) | 4.993 (4.662–5.389) | 0.773 | 5.084 (4.449–5.356) | 5.110 (4.670–5.401) | 0.874 |
| miR-296a-3p | 6.099 (5.849–6.409) | 5.883 (5.590–6.168) | 0.032 | 6.077 (5.176–6.289) | 5.949 (5.635–6.329) | 0.825 |
| miR-324-3p | 5.040 (4.827–5.385) | 5.360 (4.960–5.570) | 0.001 | 5.454 (4.695–5.689) | 5.371 (4.945–5.697) | 0.858 |
| miR-363-3p | 5.698 (5.512–6.065) | 5.576 (5.255–5.928) | 0.778 | 5.757 (5.094–5.908) | 5.712 (5.349–5.896) | 0.999 |
| miR-454-3p | 3.069 (3.069–4.437) | 3.069 (3.069–4.438) | 0.926 | 4.442 (3.654–4.635) | 4.051 (3.069–4.758) | 0.418 |
| miR-532-5p | 5.152 (4.748–5.622) | 4.917 (4.459–5.315) | 0.285 | 5.207 (4.468–5.407) | 5.192 (4.741–5.403) | 0.985 |
| miR-629-5p | 4.902 (4.651–5.566) | 5.538 (5.112–5.903) | 0.123 | 5.465 (5.306–5.918) | 5.852 (5.451–5.065) | 0.979 |
| miR-660-5p | 5.184 (5.049–5.899) | 5.465 (5.196–5.570) | 0.034 | 5.454 (4.608–5.697) | 5.4504 (5.050–5.624) | 0.992 |
Data presented as median (Q1-Q3). Samples size is indicated. Abbreviations: DCM. dilated cardiomyopathy; DCMMOD, dilated cardiomyopathy with ejection fraction ≥ 31–49%; DCMSEV, dilated cardiomyopathy with ejection fraction ≤ 30%.