Table 5.
Comparisons of single microRNAs as predictors of idiopathic DCMSEV from DCMMOD and their diagnostic value.
| miRNA | AUC (95% CI) | Sensitivity (%) | Specificity (%) | p |
|---|---|---|---|---|
| Let-7a-5p | 0.73 (0.57–0.88) |
81.58 68.42 63.16 |
38.46 46.15 61.54 |
0.0155 |
| Let-7 g-5p | 0.71 (0.55–0.86) |
75.68 72.97 64.86 |
46.67 60 66.67 |
0.0213 |
| miR-19b-3p | 0.77 (0.62–0.92) |
76.67 66.67 63.33 |
50 57.14 78.57 |
0.0050 |
| miR-25-3p | 0.70 (0.55–0.86) |
78.95 68.42 60.53 |
35.71 57.14 64.29 |
0.0259 |
| miR-29a-3p | 0.70 (0.55–0.86) |
72.5 70 52.5 |
50 57.14 71.43 |
0.0244 |
| miR-30b-5p | 0.69 (0.52–0.86) |
82.35 73.53 55.88 |
46.67 53.33 60 |
0.0354 |
| miR-30e-3p | 0.72 (0.57–0.87) |
78.38 72.97 70.27 |
35.71 42.86 64.29 |
0.0161 |
| miR-142-3p | 0.76 (0.62–0.91) |
75.86 72.41 65.52 |
46.67 60 73.33 |
0.0046 |
| miR-145-5p | 0.78 (0.65–0.91) |
78.95 73.68 65.79 |
46.15 61.54 69.23 |
0.0029 |
| miR-150-5p | 0.73 (0.58–0.89) |
84.62 79.49 69.23 |
38.46 46.15 69.23 |
0.0119 |
| miR-199a-3p | 0.72 (0.58–0.87) |
71.05 68.42 63.16 |
57.14 64.29 71.43 |
0.0145 |
| miR-210-3p | 0.68 (0.52–0.85) |
81.58 68.42 63.16 |
40 53.33 66.67 |
0.0382 |
| miR-324-3p | 0.69 (0.52–0.86) |
85.71 77.14 60 |
35.71 42.86 64.29 |
0.0417 |
| miR-660-5p | 0.73 (0.58–0.87) |
75 70 60 |
57.14 64.29 71.43 |
0.0129 |
Abbreviations: AUC, area under the curve; CI, confidence interval; DCMSEV, dilated cardiomyopathy with ejection fraction ≤ 30%; miRNA, microRNA; ROC, receiver operating characteristic.