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. 2021 Apr 6;11:7541. doi: 10.1038/s41598-021-87069-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of lifetime depression by lifetime spectrum mania interaction on FA, RD, and AD values in the cluster spanning the right middle longitudinal fasciculus and the right arcuate fasciculus. (A) The region of significant depression-by-mania effect on FA values in BD-II and UD. (B) The density plots of lifetime depression severity and lifetime spectrum mania scores (per MOODS-SR) in BD-II and UD participants. (C) The illustration of significant depression-by-mania interaction effect on FA, RD, and AD values in BD-II and UD. FA in this cluster was greatest and RD values were lowest at low levels of both lifetime depression and mania and high levels of both lifetime depression and mania; AD values were lowest at high levels of mania and low depression.