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. 2021 Apr 6;12(4):350. doi: 10.1038/s41419-021-03576-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Venn diagram analysis to determine potential miR-30d targets. b Predicted binding sequences between miR-30d and the 3′-UTR of SOX4. c–e Levels of SOX4 mRNA and protein in pancreatic cancer cells after transient transfection with lipofectamine by RT-qPCR and western blot, respectively. f, g Relative luciferase activity in Mia PaCa-2 and Panc-1 cells after transient transfection with lipofectamine. h Correlations between miR-30d and SOX4 mRNA expression in pancreatic cancer tissues (n = 35). i Correlations between miR-30d and SOX4 mRNA expression in patients in the TCGA dataset (n = 171). j OS status analysis of pancreatic cancer patients in TCGA based on SOX4 and miR-30d expression (n = 171). k RFS status analysis of pancreatic cancer patients in TCGA based on SOX4 and miR-30d expression (n = 131). *P < 0.05, **P < 0.01, ***P < 0.001.