Fig. 2. Subtype membership in the training, and validation datasets.

a MRI-based subtypes in the training and internal validation dataset and b the validation dataset. Assignability of the disease subtype, or membership probability, is shown as the distance from each vertex of the triangle. Each of vertices represent the point at which membership of a given subtype is at its maximum (100%). We assigned each subject to one subtype (shown in red, green and blue) based on their maximum probability. c, d The 80th and 90th percentiles for the probability of assignment to the dominant subtype was 99.98% and 99.99% (indistinguishable in the figure) in the training dataset. In the validation dataset these percentiles were 99.45% and 99.97% respectively.