Table 2:
Summary of Hematological Results
| POD | ||||||||
|---|---|---|---|---|---|---|---|---|
| Measurements | Baseline | 0 | 1 to 5 | 6 to 10 | 11 to 15 | 16 to 20 | 21 to 25 | 26 to 30 |
| PfHb [mg/dL] | 18 ± 3 | 13 ± 1 | 16 ± 3 | 15 ± 4 | 15 ± 1 | 16 ± 3 | 16 ± 5 | 14 ± 2a |
| LDH [IU/L] | 401 ± 31 | 315 ± 24b | 446 ± 44 | 341 ± 70b | 361 ± 83 | 357 ± 64 | 357 ± 39 | 367 ± 24a |
| Creatine Kinase [U/L] | 97 ± 45 | 153 ± 106 | 151 ± 148 | 87 ± 52 | 91 ± 54 | 87 ± 38 | 90 ± 33 | 88 ± 48a |
| WBC [K/uL] | 9 ± 2 | 7 ± 2b | 12 ± 3b | 12 ± 2b | 11 ± 2b | 12 ± 2b | 11 ± 2 | 10 ± 1a |
| Hct [%] | 35 ± 3 | 23 ± 3b | 26 ± 3b | 24 ± 3b | 26 ± 5b | 26 ± 4b | 26 ± 4b | 29 ± 4a,b |
| Hgb [g/dL] | 12 ± 1 | 8 ± 1b | 9 ± 1b | 8 ± 1b | 8 ± 2b | 9 ± 1b | 9 ± 1b | 9 ± 1a,b |
| Platelets [K/uL] | 602 ± 129 | 378 ± 123b | 417 ± 152 | 542 ± 135 | 687 ± 118 | 791 ± 139 | 630 ± 344a | 972 ± 820a |
| P-Selectin Positive Platelets [%] | 6 ± 3 | 4 ± 2 | 6 ± 3 | 6 ± 2 | 10 ± 8 | 7 ± 3 | 8 ± 4a | 8 ± 5a |
| P-Selectin Positive Platelets - PAF activated [%] | 75 ± 5 | 66 ± 11b | 72 ± 5 | 79 ± 12 | 82 ± 10 | 78 ± 11 | 80 ± 7a | 78 ± 3a |
| Soluble P-Selectin [ng/mL] | 5 ± 2 | 4 ± 1 | 4 ± 2 | 4 ± 2 | 5 ± 2 | 5 ± 2 | 4 ± 2 | 5 ± 2a |
| ALT [U/L] | 15 ± 4 | 11 ± 3 | 14 ± 3 | 13 ± 5 | 13 ± 6 | 12 ± 6 | 12 ± 7 | 13 ± 9a |
| AST [U/L] | 77 ± 12 | 60 ± 12b | 66 ± 13b | 48 ± 10b | 49 ± 6b | 44 ± 8b | 45 ± 10b | 51 ± 3a,b |
| BUN [mg/dL] | 11 ± 3 | 11 ± 4 | 13 ± 3 | 11 ± 2 | 10 ± 2 | 11 ± 3 | 9 ± 3 | 10 ± 2a |
| Creatinine [mg/dL] | 1.0 ± 0.1 | 0.8 ± 0.1b | 1.1 ± 0.2 | 0.9 ± 0.1 | 0.8 ± 0.1b | 0.8 ± 0.1b | 0.9 ± 0.1b | 0.9 ± 0.1a |
Each measurement had n = 5 unless otherwise specified.
These measurements had n = 4
Significantly different relative to corresponding baseline value (p < 0.05). PfHb = plasma free hemoglobin, LDH = lactate dehydrogenase, WBC = white blood cells, Hct = hematocrit, Hgb = hemoglobin, PAF = platelet activating factor, ALT = alanine aminotransferase, AST = aspartate aminotransferase, BUN = blood urea nitrogen.