. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: WIREs Mech Dis. 2020 Oct 7;13(2):e1507. doi: 10.1002/wsbm.1507

Table 3.

Evidence of ICC abnormalities in different GI motility disorders.

GI Motility Disorders	Histopathological Findings
Gastroparesis	Loss of ICCs in the stomach is regarded as a pathological hallmark. ^4,105
Slow transit constipation	The volume of ICC significantly decreased in all layers of sigmoid colonic specimens from patients.¹⁰⁶ Significantly decreased in the densities of ICC and enteric nerves in all layers of the patients’ sigmoid colon specimens. ¹⁰⁷
Chronic Intestinal Pseudo-Obstruction (CIPO)	Decrease or total loss of the numbers of c-kit+ cells. ^108,109 Abnormal distribution of the ICCs have also been observed.^110,111
Ileus	Ileus may be associated with ICC, myenteric neurons and nNOS immunoreactive neurons deficiency. ¹¹²
Intestinal Artesia	The distal and proximal parts of the atretic segments have a significantly lower number of ICCs per field than in the control group.¹¹³
Hirschsprung’s Disease (HD)	Reduction of each subtype of ICCs (especially ICC-IM and ICC-SMP) in the aganglionic colon region. ¹¹⁴ Sparse ICC-MP networks in the aganglionic bowel, transitional zone, and ganglionic bowel in HD patients. Reduced density of ICC-IM in the aganglionic bowel, transitional zone, and normogaglionic bowel of HD patients.^115–117 Altered ICC distribution in the entire resected bowel of HD patients.^115,118
Chronic Unexplained Nausea & Vomiting (CUNV) Syndrome	Fewer ICCs counts per field and with mild ultrastructural abnormalities compared to controls.¹¹⁹