Table 2.
Diagnostic performance of two versions of the Cognalyzer® algorithm after participants with missing EEG recordings or who had electrode placement errors and were removed from the population (PP2, n = 62)
| Diagnostic performance of cognalyzer® | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Post-inhalation | Pre-inhalation | Total | Sensitivity (95% CI) | Specificity (95% CI) | Accuracy (95% CI) | Percent false positive (95% CI) | Percent false negative (95% CI) | PPV (95% CI) | NPV (95% CI) | p value | ||
| Cognalyzer®—algorithm version 1 | ||||||||||||
| Cognalyzer® version 1—post-inhalation | 54 | 10 | 64 | 87.1 (76.1–94.3) | 83.9 (72.3–92) | 85.5 (78–91.2) | 16.1 (8–27.7) | 12.9 (5.7–23.9) | 84.4% (73.1–92.2) | 86.7% (75.4–94.1) | 0.637 | |
| Cognalyzer® version 1—pre-inhalation | 8 | 52 | 60 | – | – | – | – | – | – | |||
| Total | 62 | 62 | 124 | – | – | – | – | – | – | |||
| Cognalyzer®—algorithm version 2 | ||||||||||||
| Cognalyzer® version 2—post-inhalation | 55 | 13 | 68 | 88.7 (78.1–95.3) | 79.0 (66.8–88.3) | 83.9 (76.2–89.9) | 21 (11.7–33.2) | 11.3 (4.7–21.9) | 80.9% (69.5–89.4) | 87.5% (75.9–94.8) | 0.180 | |
| Cognalyzer® version 2—pre-inhalation | 7 | 49 | 56 | – | – | – | – | – | – | |||
| Total | 62 | 62 | 124 | – | – | – | – | – | – | |||
McNemar’s chi-squared test was used to compare the difference in performance between the diagnostic test being evaluated and the comparison standard