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. 2021 Apr 5;13:17588359211006680. doi: 10.1177/17588359211006680

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Functional Hotness Score (FHS) and tumor mutational burden (TMB) in triple-negative breast cancers (TNBCs). (a) Comparison of TMB between the low- and the high-FHS TNBCs in The Cancer Genome Atlas (TCGA). (b) Patients distribution in association with FHS and TMB in TCGA TNBCs. (c) and (d) Overall survival (OS) estimation by FHS in the high- and the low-TMB TNBC patients in TCGA with full DNA sequence data. (e) OS estimation comparing the high-FHS–high-TMB and the others and (f) high-CD8+ T cell–high-TMB and the others in TCGA TNBCs.

HiFHS, high Functional Hotness Score; LoFHS, low Functional Hotness Score.