TABLE 2.
Changes of bacterial quantity and the rates of mutant resistant to CHL and phages after 48 h incubation with AB91118 under different treatments.
| Treatment | Bacterial quantity after 48 h incubation | Mutant rates |
||
| Resistant to CHL (1 MIC) | Resistant to LQ7 (MOI 1000) | Resistant to ELQ7P-20 (MOI 1000) | ||
| CHL (1/2 MIC) | 2.70 ± 0.99 × 109 | 0.55 ± 0.03 | 4.50 ± 0.71 × 10–5 | 8.50 ± 0.71 × 10–5 |
| LQ7 (MOI 1) | 1.45 ± 0.21 × 109 | 0.40 ± 0.11 | 6.10 ± 1.55 × 10–4 | 2.80 ± 1.41 × 10–4 |
| ELQ7P-20 (MOI 1) | 1.65 ± 1.52 × 108 | 0.12 ± 0.07 | 8.70 ± 0.42 × 10–3 | 6.65 ± 0.35 × 10–3 |
| CHL + LQ7 | 1.30 ± 0.42 × 106 | 0.93 ± 0.01 | 2.25 ± 0.35 × 10–2 | 2.92 ± 1.29 × 10–3 |
| CHL + ELQ7P-20 | 4.05 ± 1.70 × 105 | 0.03 ± 0.01 | 5.96 ± 0.21 × 10–3 | 1.37 ± 0.11 × 10–3 |
| LQ7 + ELQ7P-20 | 5.65 ± 1.62 × 108 | 0.02 ± 0.01 | 8.50 ± 0.71 × 10–2 | 3.60 ± 0.57 × 10–2 |
| CHL + LQ7 + ELQ7P-20 | 3.10 ± 1.27 × 106 | 0.07 ± 0.01 | 3.75 ± 0.35 × 10–3 | 7.72 ± 0.71 × 10–4 |
| Control | 4.00 ± 0.01 × 109 | 0 | 3.00 ± 1.41 × 10–5 | 7.00 ± 1.41 × 10–5 |