TABLE 2.

Pro-apoptotic or anti-apoptotic activity of WNV and its proteins.

Virus	Viral protein	Strains	Tested cell lines	Function	References
WNV		Eg101	K562, Neuro-2a	Pro-apoptotic	Parquet et al., 2001
		3000.0259 strain	ESNC		Bimmi et al., 2003; Samuel et al., 2007
		NY385-99 strain	T98G, SK-N-MC, HEK293T, MEFs		Kleinschmidt et al., 2007; Medigeshi et al., 2007
		Sarafend strain	Vero		Chu and Ng, 2003
		9935262 strain	Midgut epithelial cells of mosquitoes		Vaidyanathan and Scott, 2006
		NY-99 strain	HeLa, 293, RD, SH-SY5Y		Joo-Sung et al., 2002
	C		MEFs, SH-SY5Y	Pro-apoptotic	Yang et al., 2010
		Sarafend strain	BHK		Bhuvanakantham et al., 2010
		NY835-99 strain	A549, HEL/18	Anti-apoptotic	Urbanowski and Hobman, 2013
		NY-99 strain	A549		Airo et al., 2018
	M	IS-98-ST1	Neuro 2a, HepG2	Pro-apoptotic	Catteau et al., 2003
	NS2A	Kunjin strain	Vero76 cells		Melian et al., 2013
	NS3	Merion strain	RD, Neuro-2a, Vero, Hela, NIH3T3		Ramanathan et al., 2006
	NS2B-NS3		RD, Neuro-2a, Vero