TABLE 4.

Brain region-specific parameter estimates for myelin water fraction generated using the Gompertz model^a.

	AR			SR			Pooled SEM			P-valueb
ROI Parameterc	a	b	g	a	b	g	a	b	g	a	b	g
Corpus callosum	0.24	–0.36	0.29	0.12	–0.57	0.26	0.107	0.281	0.099	0.072	0.280	0.827
Cerebellum	2.64	5.97	2.77	0.16	–3.85	1.04	4.097	12.513	1.186	0.333	0.222	0.039
Combined cortex	0.17	–1.02	0.31	0.12	–0.98	0.15	0.116	0.269	0.056	0.523	0.892	0.001
Combined hippocampus	0.10	–0.73	0.33	0.12	–0.67	0.27	0.033	0.147	0.056	0.554	0.711	0.346
Combined internal capsule	0.57	–0.35	0.28	0.36	–0.42	0.16	0.391	0.331	0.115	0.458	0.842	0.173
Hypothalamus	2.04	1.98	0.46	0.21	–0.45	0.54	3.031	3.018	0.324	0.334	0.205	0.849
Left cortex	0.21	–0.57	0.34	0.10	–0.86	0.13	0.144	0.811	0.169	0.206	0.573	0.062
Left hemisphere	0.12	–6.06	1.27	0.09	–1.34	0.15	0.040	8.875	1.250	0.245	0.393	0.159
Left hippocampus	0.31	–0.30	0.30	0.16	–0.72	0.27	0.173	0.332	0.095	0.212	0.110	0.623
Left inferior colliculus	2.15	14.72	8.01	0.14	–2.83	1.28	3.136	25.488	7.454	0.306	0.272	0.153
Left internal capsule	0.26	–0.28	0.41	0.60	–0.03	0.13	0.160	0.380	0.178	0.109	0.436	0.024
Left olfactory bulb	0.10	–3.93	8.93	0.09	5.34	5.95	0.057	6.651	3.883	0.853	0.254	0.447
Left putamen globus-pallidus	2.77	6.60	0.32	0.49	–0.01	0.13	4.082	11.219	0.122	0.369	0.344	0.028
Left superior colliculus	0.19	15.3	1.49	0.10	–0.67	0.59	0.098	24.494	0.908	0.108	0.296	0.134
Medulla	2.41	14.97	7.56	0.09	–1.86	5.40	3.790	29.193	1.734	0.326	0.357	0.118
Midbrain	0.13	–0.01	1.10	0.20	–1.00	0.44	0.063	1.017	0.399	0.462	0.145	0.024
Pons	2.69	15.90	12.12	0.08	–16.41	3.03	3.614	24.413	4.958	0.250	0.040	0.008
Right cortex	0.07	–4.12	0.35	0.14	–0.93	0.17	0.051	4.924	0.058	0.260	0.300	0.004
Right hemisphere	0.09	–1.19	0.53	0.21	–1.04	0.23	0.058	0.244	0.110	0.222	0.619	0.008
Right hippo	0.10	–0.76	0.32	0.09	–0.74	0.30	0.021	0.116	0.052	0.624	0.816	0.633
Right inferior colliculus	0.17	0.19	2.88	0.12	1.77	3.09	0.096	3.336	1.090	0.379	0.460	0.846
Right internal capsule	0.42	–0.19	0.20	0.34	–0.64	0.26	0.176	0.270	0.087	0.663	0.105	0.485
Right olfactory bulb	0.10	–2.62	6.53	0.10	101.90	4.89	0.048	60.775	2.337	0.899	0.317	0.486
Right putamen globus-pallidus	0.41	–0.10	0.21	0.24	–0.47	0.14	0.151	0.277	0.089	0.159	0.190	0.312
Right superior colliculus	0.11	–0.41	0.59	0.94	–0.48	0.33	0.502	0.392	0.179	0.333	0.832	0.054
Thalamus	0.19	–0.64	0.25	0.15	–0.62	0.14	0.100	0.186	0.054	0.594	0.930	0.012
Whole brain	0.13	–0.39	0.56	0.15	–2.55	0.10	0.065	2.257	0.167	0.852	0.343	0.001

^aAR, artificially reared pigs; ROI, region of interest; SEM, standard error of the mean; SR, sow-reared pigs.

^bP-values derived from two-sample t-test comparing pigs raised in different early-life environments and group-housed in a common setting starting at postnatal week 4. Significant P-values are shown in bold text for emphasis.

^cParameter estimations for each outcome were computed for maximum absolute (i.e., plateau) value (a), onset of initial developmental increase (b), and overall rate of development (g).