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. 2021 Mar 23;6(10):3580–3595. doi: 10.1016/j.bioactmat.2021.03.019

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Optimization of TSHSP hydrogel formulation. (A) Schematic diagram of HA oxidation. (B) Actual oxidation degree and oxidation efficiency profile of AHA under different sodium periodate equivalents (n = 3, error bars, mean ± SD). (C) G'_max distribution of AHA/CMC (i-iv) and GEL/PEG-SG (v) hydrogels under different formulations, macroscopic appearance of AHA/CMC hydrogels with different G'_max (vi). (D)–(F) Gelation profile of AHA/CMC (D), GEL/PEG-SG (E), and TSHSP (AHA/CMC-GEL/PEG-SG, F) formulation. (G)–(I) Macroscopic appearance of AHA/CMC, GEL/PEG-SG, TSHSP formulations (G), AHA-GEL mixture (H), and CMC-PEG-SG mixture (I). *P < 0.05, over previous oxidation degree.