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. 2021 Mar 24;12:613530. doi: 10.3389/fimmu.2021.613530

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Copyright © 2021 Cui, Huang, Zhang, Liu, Liao and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular mechanisms of action of cancer-derived IgG. Cancer-derived IgG promotes tumorigenesis in autocrine and paracrine manners.(i) Cancer-derived IgG interacts with integrins located on the tumor cell membrane and then activates downstream pathways, including FAK/Src, MEK/ERK/c-Myc and reactive oxygen species (ROS) pathways. (ii) Cancer-derived IgG interacts with different membrane receptors of other types of cells, including Siglec of T cells, Toll-like receptor (TLR) of macrophages and FcγR of natural killer (NK) cells and platelets, and further regulates the functions of these cell types. ADCC, antibody-dependent cellular cytotoxicity.