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. 2021 Mar 24;11:637604. doi: 10.3389/fcimb.2021.637604

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Copyright © 2021 Chauvet, Chhuon, Lipecka, Dechavanne, Dechavanne, Lohezic, Ortalli, Pineau, Ribeil, Manceau, Le Van Kim, Luty, Migot-Nabias, Azouzi, Guerrera and Merckx

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parasite replication in HbAA and HbAS RBCs assessed by flow cytometry (A) and by blood smears (B). Invasion of 2 HbAA (HbAA1 and HbAA2) and 2 HbAS (HbAS1 and HbAS2) blood samples from the cryobank of the the French National Immunohematology Reference Laboratory (CNRGS), was realized at t = 0h. Parasitemia was assessed every 24h. To visualize the fold increase of parasitemia, all parasitemia values were divided by the initial parasitemia measured 24h post-infection. Technical duplicates were performed for each donor, and replicate values for each point were loaded on the graph. Unpaired Mann-Whitney t-test (p-value<0.05) was used to compare values from HbAA and HbAS groups at 24h, 72h, 120h and 168 h., asterisks (*) indicate significantly different values (A). Parasite development in one HbAA (HbAA1 as a reference) and 3 HbAS (HbAS1, HbAS2 and HbAS3) blood donors erythrocytes. Invasion of fresh blood samples was realized at t = 0h. Blood smears were performed every 24h for six days. At day 6, blood smears were realized right before MACS collection (B).