TABLE 1.
The 3D view of binding interactions between tested benzimidazole drugs and NZO-binding pocket within Tubulin subunit B and D (PDB: 5CA1) beside the solved NZO complex (Native) and the docked complex (Docked). Red dashed lines refer to hydrogen bonds, while the black ones denote hydrophobic interactions.
| Drug | Protein (5CA1) subunit B | Protein (5CA1) subunit D |
|---|---|---|
| NZO (native) |
|
|
| NZO (docked) |
|
|
| Mebendazole |
|
|
| Albendazole |
|
|
| Ciclobendazole |
|
|
| Fenbendazole |
|
|
| Flubendazole |
|
|
| Oxibendazole |
|
|
| Oxfendazole |
|
|
| Thiabendazole |
|
|
| Bendazole |
|
|