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. 2021 Mar 24;12:650752. doi: 10.3389/fneur.2021.650752

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Copyright © 2021 Kim, Lee and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology of the inner ear. The rats in the intratympanic gentamicin injection (ITGM) only group show a near-complete loss of both the type I and II hair cells and a collapse of the sensory epithelium both in the saccule (A,D) and utricle (G,J). In contrast, the rats in the ITGM combined with intramuscular deferoxamine (DFO) injection (ITGM+DFO) and normal control (ITNS) groups showed a relatively well-preserved sensory epithelium including the hair cells, cilia, and otolith layer in both the saccule (B,C,E,F) and utricle (H,I,K,L). Open arrow, the type I hair cell; double open arrow, the type II hair cell; closed arrow, the otoconia; filled arrow head, the supporting cell; lined arrow head, the cilia.