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. 2021 Mar 24;15:613798. doi: 10.3389/fnbeh.2021.613798

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Copyright © 2021 Fuerte-Hortigón, Gonçalves, Zeballos, Masa, Gómez-Nieto and López.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CB1 immunoreactivity in the GASH/Sal brain. (A) Micrographs showing CB1 receptors (arrows), around the soma and the initial part of the axon of unstained Purkinje cells, constituting the so-called “Pinceaux” formation. (B) Strong and diffuse CB1 immunoreactivity in the dorsal cochear nucleus. Neurons of this nucleus appear immunostained. (C) Neurons of the posteroventral cochlear nucleus showing slight immunoreactivity for CB1R. (D) CB1 expression in the central nucleus of the inferior colliculos, exhibiting diffuse immunoreactivity. Scarce medium-size neurons appears labeled intracelularlly. Asterix indicate small immunoreactive glial cells. (E) CB1 immunoreactivity is observed in not strong delineate fibers in the substantia nigra. (F,G) CB1R immunostaining in the basomedial (BML) and basolateral (BLA) amygdala, showing the neuropil granular/reticular staining. Labeling is slightly weaker in BLA. (H) Strong CB1 immunoreactive fibers with a plexiform pattern in the motor cortex. (I) High CB1 expression in the globus pallidus, where a strong network of immunoreactive fibers surround immunonegative-traversing fascicles (arrows). (J) CB1 immunoreactivity of the Olfactory bulb, exhibiting moderate immunoreactivity of Granule cell layer (GrO) and weakly immunoreactivity of the external plexiform layer (EPL). Asterisk indicates small immunoreactive glial cells. (K–M). CB1 expression in rat hippocampal formation. CB1 positive fibers surround the somata of pyramidal cells in CA1 (K) and CA3 (L) fields of the hippocampus. Numerous varicosities, corresponding to terminals is apparent. Receptor levels are particularly high in the granule cell layer (sratum granulosum) of the dentate gyrus. Scale bar = 20 μm for all panels. BLA, Basolateral amygdala nucleus; BMA, Basomedial amygdala nucleus; CA1–3, Cornu Ammonis area 1–3 CB, Cerebellum; DCN, Dorsal cochlear nucleus, DG, Dentate gyrus; fc, Fusiform cells; EPL, External plexiform layer olfactory bulb gc, Globular cells; GP, Globus pallidus; GrO, Granule cell layer olfactory bulb; hil, Hilus; IC, Inferior colliculus; mc, Multipolar cells; Mo, Motor cortex; OB, Olfactory bulb; oc, Octopus cells; pc, Purkinje cells; PVCN, Ventral cochlear nucleus, posterior part; SN, Substantia nigra; s.g., Stratum granulosum; s.p., Stratum pyramidale.