Table 3.
Prognostic factors of the outcomes pregnancy related to the global check-up.
| Characteristicsa | Early pregnancy loss* (n = 20) | No pregnancy (n= 33) | Failure*** (n=53) | Live Birth** (n= 51) | p-valueb | p-valuec |
|---|---|---|---|---|---|---|
| Minor karyotype abnormalities | 0 | 1 (50%) | 1 (50%) | 1 (50%) | 0.74 | 0.77 |
| Increased Homocysteine | 2 (25%) | 2 (25%) | 4 (50%) | 4 (50%) | 0.86 | 0.55 |
| Presence of autoimmune antibodies | 4 (44%) | 0 (0%) | 4 (44%) | 5 (66%) | 0.83 | 0.08 |
| TSH greater than 2,5 | 18 (20%) | 28 (31%) | 46 (51%) | 43 (49%) | 0.70 | 1 |
| HYSTEROSCOPY | ||||||
| Necessity of a surgery procedure | 7 (23%) | 9 (30%) | 16 (53%) | 14 (47%) | 0.93 | 0.95 |
| Malformation | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) | 0.28 | 0.63 |
|
Uterine ultrasound check-up Endometrial thickness (mm) |
||||||
| 0.73 | 0.80 | |||||
| <7 mm | 7 (22%) | 9 (28%) | 16 (50%) | 16 (50%) | ||
| >7mm | 13 (19%) | 24 (35%) | 37 (54%) | 32 (46%) | ||
| Endometrial volume | 0.58 | 0.86 | ||||
| < 2ml | 5 (18%) | 9 (32%) | 14 (50%) | 14 (50%) | ||
| >2ml | 13 (20%) | 23 (36%) | 36 (56%) | 28 (44%) | ||
| Sub endometrial VFI | 1.2 ± 1.6 | 1.2 ± 2 | 1.2 ± 1.7 | 1.9 ± 4.1 | 0.33 | 0.57 |
| Pulsatility Index (R +L) | 5.3 ± 4.4 | 4 ± 5 | 4. 7± 4.2 | 5.5 ± 4.6 | 0.31 | 0.49 |
| Diagnosis of Uterine Immune Profile | ||||||
| Normal | 11 (42%) | 7 (27%) | 18 (69%) | 8 (31%) | 0.06 | 0.02 |
| Dysregulated | 9 (5%) | 26 (33%) | 35 (45%) | 43 (55%) | 0.01 | 0.01 |
| Low immune activation profile | 1 (4%) | 11 (46%) | 12 (50%) | 12 (50%) | ||
| High/over immune activation profile | 7 (18%) | 7 (18%) | 14 (36%) | 25 (64%) | ||
| Mixted profile | 1 (7%) | 8 (53%) | 9 (60%) | 6 (40%) | ||
| Pathological sperm fragmentation index (>20%) | 9 (27%) | 8 (24%) | 17 (51%) | 16 (49%) | 0.36 | 0.32 |
a
Continuous data are presented as mean ± standard deviation; categorical data are presented as number (percentage).
k
Pearson’s Chi-square test.
u Mann-Whitney test.
*Early pregnancy loss was defined as a spontaneous fetal demise at less than 12 weeks of gestational age.
**The live birth was defined as delivery of a viable infant at 22 weeks or more of gestation.
***The failure Group included early pregnancy loss and patients who have not had a pregnancy.
b
p value between the 2 groups (Failure/Live Birth).
c
p value between the 3 groups (early pregnancy loss/no pregnancy/Live birth).