Fig. 6.

PELP1 is needed for TFAP2C‐mediated BC progression. SCID mice implanted with an E2 pellet were injected with ZR75‐control, ZR75‐TFAP2C, ZR75‐PELP1 shRNA, ZR75‐TFAP2C‐PELP1 shRNA cells into the mammary fat pad, and tumor growth was measured at 5 days intervals. (A) Tumor volume (n = 6) is shown in the graph. *P < 0.05; ****P < 0.0001 by two‐way ANOVA with Tukey for post hoc test. B,C, Status of Ki‐67 expression as a marker of proliferation and RET was analyzed using IHC. Quantification of Ki‐67 and RET expression is shown (B). (C) Representative IHC images of Ki‐67 and RET are shown. Scale bar = 100µm. Data are shown as the means ± SEM. ***P < 0.001; ****P < 0.0001 by Student's t‐test.