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. 2021 Mar 9;15(4):866–886. doi: 10.1002/1878-0261.12910

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© 2021 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 8 — PRDM1 activated TOX gene transcription. (A) Transcription factor networks that drive the expression of TOX in total CD8⁺ T cells predicted by SCENIC. (B) Heatmap of regulators predicted by SCENIC that drives the expression of TOX in CD8⁺ T cells clusters. The PRDM1 regulon is indicated in red. (C) A conserved PRDM1‐binding motif at the TOX promoter was predicted by JASPAR. (D) Dual‐luciferase reporter assays of Jurkat cells transfected with PRDM1 overexpression plasmid and reporter plasmid containing TOX promoter (ANOVA, P < 0.0001, n = 3). Jurkat cells transfected with a blank pGL3 plasmid served as a negative control. Data are presented as means ± SD.