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Schematic model of the regulation of DDX21 and CEP55 by N‐Myc. (A) N‐Myc binds to the DDX21 gene promoter containing the noncanonical E‐boxes, leading to DDX21 transcriptional activation, and increased DDX21 mRNA and protein expression. (B) DDX21 binds to the CEP55 gene promoter to facilitate CEP55 transcriptional elongation, leading to elevated CEP55 mRNA and protein expression, as well as cell cytoskeletal stability and cell proliferation. TSS, transcription start site.
