Fig. 8.
Schematic model of the role of circATRNL1/miR‐378/Smad4 axis in ovarian cancer. circATRNL1 is reduced in ovarian cancer cells, leading to an elevation of miR‐378 and subsequently a reduction of Smad4. As a result, AKT signaling is activated, promoting the cancer cell proliferation, angiogenesis, as well as metastasis.