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. 2021 Jan 11;15(4):1217–1233. doi: 10.1002/1878-0261.12893

Fig. 8.

Fig. 8

Schematic model of the role of circATRNL1/miR‐378/Smad4 axis in ovarian cancer. circATRNL1 is reduced in ovarian cancer cells, leading to an elevation of miR‐378 and subsequently a reduction of Smad4. As a result, AKT signaling is activated, promoting the cancer cell proliferation, angiogenesis, as well as metastasis.