Table 1.

Univariate and multivariate Cox regression analysis of NKX2‐1‐AS1 and survival in patients with gastric cancer. CI, confidence interval; HR, hazard ratio; TNM, tumor node metastasis.

Clinical variables	Univariate analysis		P value	Multivariate analysis		P value
	HR	95% CI		HR	95% CI
Overall survival
Gender (male vs. female)	0.736	0.498–1.196	0.276
Age (≥60y vs. <60y)	0.949	0.621–1.448	0.936
Tumor location (down vs. upper/middle)	0.806	0.518–1.267	0.293
Tumor size (≥5 cm vs. <5 cm)	1.521	1.020–2.276	0.134
Differentiation (poor vs. moderate/well)	1.845	0.937–3.745	0.071
T stage (T3‐T4 vs. T1‐T2)	4.245	1.640–11.018	0.005
N stage (N2‐N3 vs. N0‐N1)	2.317	1.287–3.546	0.002
TNM stage (III‐IV vs. II‐I)	3.898	2.136–6.945	<0.001	2.745	1.575‐5.136	0.004
Distant metastasis (yes vs. no)	3.389	1.955–5.896	<0.001	2.054	1.201‐3.634	0.008
Infiltration of peritumoral tissues (yes vs. no)	2.753	1.743–3.845	<0.001	1.934	1.245‐3.121	0.003
Peritoneum dissemination (yes vs. no)	3.834	2.034–7.145	<0.001
NKX2‐1‐AS1 expression (high vs. low)	0.358	0.261–0.448	<0.001	0.383	0.297‐0.501	0.005
Progression‐free survival
Gender (male vs. female)	0.856	0.534–1.319	0.390
Age (≥60y vs. <60y)	0.813	0.498–1.289	0.359
Tumor location (down vs. upper/middle)	0.764	0.491–1.125	0.163
Tumor size (≥5 cm vs. <5 cm)	1.296	0.759–1.868	0.387
Differentiation (poor vs. moderate/well)	1.176	0.618–2.065	0.721
T stage (T3‐T4 vs. T1‐T2)	5.780	1.792–17.265	0.003
N stage (N2‐N3 vs. N0‐N1)	2.578	1.389–4.179	0.002
TNM stage (III‐IV vs. II‐I)	3.619	1.895–6.191	<0.001	2.571	1.378–4.701	0.002
Distant metastasis (yes vs. no)	3.197	1.765–5.329	<0.001	1.921	1.102–3.397	0.037
Infiltration of peritumoral tissues (yes vs. no)	2.486	1.576–3.793	<0.001	1.846	1.138–2.878	0.009
Peritoneum dissemination (yes vs. no)	2.354	1.104–4.943	0.039
NKX2‐1‐AS1 expression (high vs. low)	0.319	0.223–0.407	<0.001	0.337	0.227–0.438	0.001

The bold type represents P values smaller than 0.05.