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. 2021 Mar 23;2(2):100404. doi: 10.1016/j.xpro.2021.100404

Figure 6.

Figure 6

Comparison between conventional crosslinked ChIP (faxChIP) and native ChIP (fanChIP)

The distribution pattern of RNAP2 is different between the two methods. RNAP2, whose heptapeptide repeats in the C-terminal domain (CTD) are phosphorylated on Ser5 (RNAP2 Ser5-P), tends to accumulate at transcription start sites (TSSs) in faxChIP (black), whereas it is more dispersed in fanChIP (blue). RNAP2, whose heptapeptide repeats in the CTD are not phosphorylated (RNAP2 non-P), is enriched at TSSs in fanChIP.