Table 4. Laboratory findings of 93 survivors on days 1, 4, 7, and 10.
| Variable | Day 1 | Day 4 | Day 7 | Day 10 | P value |
|---|---|---|---|---|---|
| Inflammatory | |||||
| White blood cell count, 109/L | 5.9 (4.1, 7.9) | 6.7 (4.7, 8.8)* | 7.0 (5.2, 9.4)* | 6.8 (5.5, 8.4) | 0.0259# |
| Lymphocyte count, 109/L | 0.8 (0.6, 1.3) | 1.0 (0.6, 1.3) | 1.1 (0.6, 1.6)* | 0.8 (0.5, 1.3) | 0.3607 |
| C-reactive protein, mg/L | 35.3 (14.7, 61.8) | 19.6 (10.5, 34.8)* | 3.6 (1.8, 13.9)* | 5.1 (2.1, 24.5)* | <0.0001# |
| Procalcitonin, ng/mL | 0.04 (0.04, 0.05) | 0.04 (0.04, 0.05)* | 0.05 (0.05, 0.05) | 0.04 (0.04, 0.04) | 0.8191 |
| Electrolyte | |||||
| Sodium, mmol/L | 137.2 (136.1, 138.5) | 136.9 (135.9, 138.8) | 136.6 (135.6, 137.6) | 136.4 (135.7, 137.1) | 0.6937 |
| Potassium, mmol/L | 3.8 (3.5, 4.1) | 3.8 (3.6, 4.1) | 3.8 (3.5, 4.2) | 3.7 (3.5, 4.0) | 0.4949 |
| Coagulation function | |||||
| Hemoglobin concentration, g/L | 123.0 (115.0, 135.0) | 120.0 (114.0, 130.0)* | 119.0 (111.0, 132.5)* | 119.0 (110.0, 129.0)* | <0.0001# |
| Platelet count, 109/L | 194.0 (147.0, 264.0) | 206.5 (156.0, 276.5) | 232.0 (176.5, 289.0)* | 200.0 (137.0, 224.0) | 0.0327# |
| Prothrombin time, s | 13.0 (12.4, 13.8) | 13.1 (12.4, 13.8) | 12.9 (12.2, 14.0) | 13.2 (12.2, 14.4) | 0.4215 |
| Activated partial thromboplastin time, s | 35.2 (32.1, 39.1) | 34.2 (32.3, 37.3) | 33.5 (31.3, 37.8) | 30.5 (26.1, 35.6)* | 0.0007# |
| D-dimer, mg/L | 0.4 (0.3, 1.0) | 0.6 (0.2, 1.5) | 1.0 (0.4, 3.0) | 1.4 (0.7, 11.0)* | 0.0253# |
| Fibrinogen, g/L | 4.2 (3.6, 4.8) | 3.9 (3.2, 4.6)* | 3.4 (2.8, 4.1)* | 3.4 (2.6, 4.1)* | <0.0001# |
| Red blood cell volume, % | 37.2 (34.9, 40.2) | 36.8 (34.7, 39.1)* | 36.0 (34.0, 39.7)* | 37.6 (33.8, 39.1)* | 0.0112# |
| Liver function | |||||
| Alanine aminotransferase, U/L | 27.0 (17.0, 43.5) | 26.5 (18.0, 39.2) | 24.0 (18.0, 48.0) | 29.0 (20.0, 39.5) | 0.5912 |
| Aspartate aminotransferase, U/L | 26.0 (18.5, 43.0) | 23.0 (17.0, 32.0) | 18.0 (14.0, 28.0)* | 19.0 (15.5, 26.0)* | <0.0001# |
| Total bilirubin concentration, μmol/L | 9.5 (7.0, 13.7) | 10.5 (7.4, 14.1) | 12.0 (7.2, 15.4)* | 13.5 (10.2, 18.5)* | 0.0035# |
| Albumin, g/L | 35.9 (32.9, 38.8) | 33.4 (30.1, 35.9)* | 31.9 (29.1, 35.2)* | 31.9 (28.1, 34.2)* | <0.0001# |
| Lactate dehydrogenase, U/L | 278.0 (225.0, 356.0) | 256.0 (203.5, 326.0)* | 226.0 (185.5, 285.5)* | 209.0 (171.0, 245.5)* | <0.0001# |
| Renal function | |||||
| Blood urea nitrogen, mmol/L | 5.7 (4.2, 7.1) | 5.9 (4.8, 6.8) | 6.0 (4.8, 7.4)* | 6.4 (4.9, 7.5) | 0.0082# |
| Serum creatinine concentration, μmol/L | 68.0 (57.5, 81.0) | 66.0 (56.0, 78.0) | 63.0 (53.0, 75.8)* | 68.0 (56.0, 80.2)* | 0.6950 |
| Cardiac function | |||||
| Creatine kinase, U/L | 86.2 (51.6, 142.9) | 74.1 (52.8, 151.7) | 41.3 (32.0, 69.6)* | 35.6 (24.0, 60.7)* | 0.0019# |
| Cardiac troponin I, pg/mL | 30.0 (10.0, 30.0) | 20.0 (10.0, 30.0) | 10.0 (10.0, 27.5) | 15.0 (10.0, 20.0) | 0.0409# |
| Brain natriuretic peptide, pg/mL | 224.0 (55.8, 480.5) | 234.0 (131.0, 681.0) | 163.0 (73.5, 349.0) | 202.0 (87.0, 520.0) | 0.3901 |
| Oxygenation | |||||
| Oxygen saturation | 97.0 (94.0, 98.0) | 96.0 (94.5, 98.5) | 97.0 (94.0, 99.0) | 98.0 (96.0, 99.0) | 0.7814 |
| Partial pressure of oxygen, mm Hg | 84.0 (72.0, 94.0) | 84.0 (73.5, 110.0)* | 86.0 (68.0, 117.0)* | 89.0 (78.5, 117.5)* | <0.0001# |
| Oxygenation index | 303.4 (233.3, 360.6) | 282.8 (218.2, 398.3) | 305.4 (215.2, 375.8)* | 336.4 (240.9, 366.0) | 0.1168 |
Values are medians (interquartile ranges). P values were calculated by mixed linear models. #, P values indicates statistical significance (P<0.05); *, significantly different from the values of Day 1. Bonferroni’s method was used to compare with the values of Days 1, 4, 7 and 10.