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. 2021 Mar 28;22(4):e51404. doi: 10.15252/embr.202051404

Figure 4. Association of FXR2P mRNA targets with epilepsy.

Figure 4

  1. Overlap between the 488 FXR2P targets and epilepsy risk genes (75 of 1,089; Fisher's exact test, P < 0.001).
  2. String database was used to classify FXR2P and epilepsy risk genes that are part of one network.
  3. Validation of RIP‐seq by RT–qPCR. Shown are the correlation of the enrichment observed in log2 RIP‐seq (X‐axis) and log2 RT–qPCR (Y‐axis) for eight epilepsy‐relevant FXR2P targets (red) and eight FXR2P non‐targets (black). Each point represents an individual mRNA, quantified using both methods (r = 0.8551, ***P < 0.001). mRNAs are normalized for the average of all the 16 mRNAs.