Table 1.

List of ERAP1 allotypes and their frequency in different populations

Allotype	Amino acid composition at each SNP									Population allotype frequency (%)
	56	127	276	346	349	528	575	725	730	ALL	AFR	AMR	EUR	EAS	SAS
1	E	P	I	G	M	K	D	R	Q	6.1	0.5	12.1	14.0	0.0	7.6
2	E	R	I	G	M	K	D	R	Q	25.6	28.1	22.6	14.4	42.6	18.4
3	E	R	I	G	M	K	D	R	E	8.5	11.4	5.8	6.6	2.7	14.5
4	E	R	I	G	M	R	D	R	E	3.2	3.0	8.9	1.0	2.4	2.4
5	E	R	I	D	M	R	D	R	E	6.2	8.4	3.9	6.3	0.0	10.9
6	E	P	I	G	M	R	D	R	E	5.8	4.0	10.2	9.2	0.7	6.5
7	K	P	I	G	M	R	D	R	E	7.2	2.9	8.5	4.1	17.1	5.0
8	E	P	M	G	M	R	D	R	E	21.8	17.4	14.0	21.5	28.5	26.7
9	E	P	M	G	M	R	N	R	E	0.1	0.0	0.4	0.4	0.0	0.0
10	E	P	I	G	V	R	N	Q	E	9.6	3.5	12.4	22.4	5.8	6.5
Subtotal										94.1	79.2	98.8	99.9	99.8	98.5
11	E	P	I	D	M	R	D	R	E	2.7	9.9	0.7	0.1	0.0	0.0
12	K	P	I	D	M	R	D	R	E	1.4	5.2	0.1	0.0	0.0	0.0
13	E	P	I	G	V	R	N	R	E	0.8	3.0	0.1	0.0	0.0	0.0
14	E	P	M	G	M	R	N	Q	E	0.4	1.7	0.0	0.0	0.0	0.0
15	E	R	M	G	M	R	D	R	E	0.2	0.5	0.0	0.0	0.1	0.1
16	E	P	M	G	M	R	D	R	Q	0.12	0.0	0.0	0.0	0.0	0.6
Subtotal										5.6	20.3	0.9	0.1	0.1	0.7
Total										99.7	99.5	99.7	100	99.9	99.2

AFR, African; ALL, all populations cumulatively; AMR, American; EAS, East Asian; EUR, European; SAS, South Asian.

Bold indicates membership in the ALL population. Italics indicates subtotals and totals.