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. 2021 Jan 23;11(5):1437–1462. doi: 10.1016/j.jcmgh.2021.01.009

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Biliary genes exhibit similar expression across organoids derived from different Sox9^EGFPsubpopulations. (A) Sox9 and Spp1 are not differentially expressed in BEC or TNFα media, but Krt19 is enriched in GFP^low-derived organoids relative to GFP^high-derived organoids in TNFα media only, exhibiting an expression pattern similar to in vivo results. (B) Cyr61 is significantly up-regulated in GFP^high-derived BEC media organoids relative to GFP^sub-derived TNFα media. Although Klf6 is not significantly regulated between populations and conditions, it trends toward increased expression in GFP^low-derived organoids in both BEC and TNFα media. (C) WNT target genes Myc and Ccnd1 are not differentially expressed between populations and conditions (letters indicate grouping by significance, P < .05, one-way analysis of variance and Tukey test; n.s. = not significant).