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. 2021 Feb 10;8(7):2002567. doi: 10.1002/advs.202002567

Figure 2.

Figure 2

Characterization of microbubbles in terms of their morphology, size, biocompatibility, stability, and ultrasound contrast enhancement capacity. A) Optical microscopy images of OS MBs (filling gas: O2/SF6 = 8/2) reconstituted from lyophilized powders of the precursor PFH emulsions; the inset is an optical image of an OS MB solution in a glass vial. B) Size and size distribution of precursor PFH emulsions, SF MBs, OS MBs (filling gas: O2/SF6 = 8/2), and OX MBs. C) Concentration variations of SF MBs, OS4:6 MBs, OS8:2 MBs, OS9:1 MBs, and OX MBs incubated at 37 °C for 1 h (initial concentration: ∼2 × 107 MBs mL−1). D) Ultrasound images of SF MBs, OS MBs, and OX MBs in the gel phantom at specific time intervals (MI = 0.06, frequency = 9 MHz). E) Relative average gray values of ultrasound images of SF MBs, OS MBs, and OX MBs to initial average gray values (t = 0 s) obtained from the time‐series ultrasound images in panel D. F) Cell viability of CNE2 cells treated with OS MBs at different concentrations for 24 and 48 h (n = 3, *p = 0.032 for 24 h and *p = 0.025 for 48 h compared with the control group).