Skip to main content
. 2021 Feb 10;8(7):2003572. doi: 10.1002/advs.202003572

Figure 13.

Figure 13

Schematic diagram of the in situ vaccine effect produced by combination of RT + BNP. a) Interaction of BNP and TME, and enhancement of APCs uptake and activation. b) Schematic description of the in situ vaccine effect initiated by combined RT + BNP. BNP could capture the neoantigen released by RT. The BNP‐neoantigen complex subsequently undergoes enhanced APCs uptake and immune activation due to the abundant PAMPs on the bacterial membrane coating of BNP. After the endocytosis of BNP, released CpG could activates TLR9, which is beneficial for APCs maturation. The mature APCs present neoantigen to CD4+ and CD8+ T cells and unregulated the secretion of pro‐inflammatory cytokines that activate antitumor immune response. c) Composition of the BNP and functions of every component. Reproduced with permission.[ 91 ] Copyright 2019, Wiley‐VCH.